学习经历
1986，暨南大学，化学，学士
1989，暨南大学，分析化学，硕士
2006，中国科学院安光所，光学博士
工作经历
1989， 暨南大学化学系，教学与科研
1999，分析化学，硕士研究生导师
2010，生物医学工程，博士研究生导师
2003，香港大学化学系，访问学者
2013，美国伊利诺大学，访问交流
2014，英国剑桥大学等高校，访问学习
2015，美国加州大学，访问学者
研究方向
主要研究方向为生物分析与生物纳米技术，包括基于纳米生物传感新策略的设计与构建，开展对肿瘤标志物、基因、免疫分子、细胞及其功能等研究；研发新型纳米探针，运用纳米技术开展对生物界面单分子单细胞分析；在细胞和分子水平上获取化学与生物信息，发展对生物体系研究以及对疾病诊断分析的新技术新方法。
主要论文（通讯作者）
1.Dual electrochemiluminescence signal system for in situ and simultaneous evaluation of multiple cell-surface receptors. ACS Appl Mater Interfaces 2017, 9, 2074.
2. Label-free quartz crystal microbalance with dissipation monitoring of resveratrol effect on mechanical changes and folate feceptor expression levels of living MCF‑7 cells: A model for screening of drugs. Anal Chem 2015, 87, 4797.
3. Real-time monitoring of mechanical changes during dynamic adhesion of erythrocytes to endothelial cells by QCM-D.Chem. Commun2015,51, 11449.
4. A sensitive electrochemiluminescence cytosensor for quantitative evaluation of epidermal growth factor receptor expressed on cell surfaces. Anal Chim Acta 2015,881,148.
5. Label-free and dynamic evaluation of cell-surface epidermal growth factor receptor expression via an electrochemiluminescence cytosensor. Talanta 2016, 150, 286.
6. Gold nanoprobes-based resonance rayleigh scattering assay platform:sensitive cytosensing of breast cancer cells and facile monitoring of folate receptor expression.Biosensors & Bioelectronics2015,74,165.
7. In-situ detection of resveratrol inhibition effect on epidermal growth factor receptor of living MCF-7 cells by atomic force microscopy. Biosensors & Bioelectronics2014,56,271-277.
8.A novel electrochemical biosensor for monitoring protein nitration damage affected by NaNO2 / hemin/H2O2，Biosensors & Bioelectronics 2014,54,628..
9. A novel gold nanoparticle-doped polyaniline nanofibers-based cytosensor confers simple and efficient evaluation of T-cell activation. Biosensors & Bioelectronics 2013,50,167.
10. A label-free electrochemiluminescence cytosensors for specific detection of early apoptosis，Biosensors & Bioelectronics 2013,49,46.
11. Poly(3,4-ethylenedioxythiophene)/germanium organic-inorganic hybrid thin films: substrate- induced synthesis, enhanced photoelectrochemical and photocatalytic properties. Rsc Advances 2016, 6, 601.
12. A glassy carbon electrode modified with in-situ generated chromium-loaded CdS nanoprobes and heparin for ultrasensitive electrochemiluminescent determination of thrombin.
Microchimica Acta 2016, 183, 123.
13. Dynamic evaluation of cell-secreted interferongamma inresponse to drug stimulation via a sensitive electro-chemiluminescence immunosensor based on a glassy carbon electrode modified with graphene oxide, polyaniline nanofibers, magnetic beads, and gold nanoparticles.
Microchimica Acta 2016, 183,1739.
14. Multifunctional optical probe based on gold nanorods for detection and identification of cancer cells. Sensors and Actuators B: Chemical 2014, 191,741.
15. Facile synthesis of multifunctional germanium nanoparticles as a carrier of quercetin to achieve enhanced biological activity. Chem-Asian J. 2014, 9,2272.
16. A novel strategy for real-time and in situ detection of cytochrome c and caspase-9 in Hela cells during apoptosis，Analyst2014, 139, 2499.
17. An efficient nanomaterial-based electrochemical biosensor for sensitive recognition of drugresistant leukemia cells. Analyst 2014, 139, 3629.
18. Facile solution routes for the syntheses of water-dispersable germanium nanoparticles andtheir biological applications. Materials Letters 2013, 109,108.
承担课题
1.国家自然科学基金(No. 21375048 )“实时原位检测细胞表面RTK受体-生长因子配体分子识别行为的新方法研究”，主持。
2.国家自然科学基金(No. 21071064 ) “新型多酚锗化合物及其抑制酪氨酸蛋白激酶抗肿瘤作用研究” , 主持。
3. 科技部973重大项目子项目(No.2010CB833603 ) “基于细胞传感器对抗体-抗原分子识别与功能基础研究”, 主持。
4. 广东省自然科学基金（No.0211090）,“扫描探针显微镜对转铁蛋白及受体分子识别的探测”, 主持。
5. 广州市科技计划项目（No.2003Z3-D2041）“转铁蛋白导向纳米药物的制备及其靶向作用的探测”，主持。
6.国家自然科学基金海外合作研究项目（No.30828028）“近场光学研究γδT细胞免疫的分子机制”， 主要成员。
讲授课程
主讲过《分析化学》《仪器分析》《新型分离技术》等本科课程以及《生物分析化学》《纳米材料与生物技术》等研究生课程。
社会职务
广东省化学学会第七届理事会理事，分析化学专业委员会副主任委员，《分析测试学报》第五届编委会编委。
