个人信息

头像

姓名: 赵剑豪

部门: 化学与材料学院

直属机构: 化学与材料学院

性别:

职务:

职称: 副教授

学位: 博士

毕业院校: 中国科学院理化技术研究所

联系电话:

电子邮箱: jhzhao@jnu.edu.cn

办公地址:

通讯地址:

邮编:

传真:

荣誉奖励:

联系方式

E-mail: jhzhao@jnu.edu.cn

个人简介


赵剑豪暨南大学材料科学与工程系副教授1999年获中山大学化学专业学士学位,2002中山大学高分子化学与物理专业硕士学位2005年获中国科学院理化技术研究所有机化学专业博士学位,2005.07至今任职于暨南大学材料科学与工程系从事材料学研究2009-2010University of Delaware美国)访问学者。研究方向主要包括角膜接触镜材料、抗肿瘤纳米药物载体材料创伤修复材料、骨组织工程材料和环境友好高分子材料。主持国家自然科学基金广东省自然科学基金广东省科技计划项目广州市科技项目等10多项,发表SCI论文70篇,参编论著1本,获授权中国发明专利15件,技术转让2件,获教育部科学技术发明二等奖1广东省科学技术发明二等奖2


荣誉与奖励

2019年入选“暨南双百英才——暨南教学名师”

2017年获暨南大学化学与材料学院第一届“本科教学院长奖”

2015年获暨南大学本科教学校长奖

2012年获广东省科学技术二等奖:表面液晶态仿生技术及其增进心血管医疗器械抗凝血功效的应用研究(R4)






学习经历

2002.9-2005.6,中国科学院,理化技术研究所,高分子化学博士学位

1999.9-2002.6,中山大学,高分子所,高分子化学硕士学位

1995.9-1999.6,中山大学,化学院,化学学士学位


工作经历

2008.10-至今,暨南大学,化学与材料学院材料科学与工程系,副教授

2009.5-2010.4,University of Delaware(美),访问学者

2005.7-2008.09,暨南大学,材料科学与工程系,讲师


研究方向

角膜接触镜材料、抗肿瘤纳米药物载体、创伤修复材料、骨修复材料、环境友好材料


主要论文

1. Tao Ouyang#, Shuxian Su#, Haotian Deng, Yuying Liu, Lishu Cui, Jianhua Rong, Jianhao Zhao*. Superhydrophilic poly(2-hydroxyethyl methacrylate) hydrogel with nano-silica covalent coating: a promising contact lens material for resisting tear protein deposition and bacterial adhesion, ACS Biomaterials Science & Engineering, 2023, 9, 5653-5665. (IF 5.8)

2. Fei Zhou#, Yang Yang#, Yuying Liu, Haotian Deng, Jianhua Rong, Jianhao Zhao*. A calcium hydroxide/oleic acid/phospholipid nanoparticle induced cancer cell apoptosis by the combination of intracellular calcium overload and lactic acidosis elimination, Journal of Materials Chemistry B, 2023, 11, 5856-5869  (IF 7.571)

3. Fei Zhou#, Huiru Li#, Yuying Liu, Haotian Deng, Jianhua Rong, Jianhao Zhao*. Hyaluronan derivative decorated calcium carbonate nanoparticle as a potential platform for breast cancer synergistic therapy via blood coagulation and drug delivery. Journal of Drug Delivery Science and Technology, 2023, 83, 104406 (IF 5.062)

4. Xilin Lin#, Jinqiang Liu#, Fei Zhou, Yangtao Ou, Jianhua Rong, Jianhao Zhao*. Poly(2-hydroxyethyl methacrylate-co-quaternary ammonium salt chitosan) hydrogel: A potential contact lens material with tear protein deposition resistance and antimicrobial activity. Biomaterials Advances, 2022, 136, 212787 (IF 7.328)

5. Huaqiang Li#, Shuqiang Zhuang#, Yang Yang, Fei Zhou, Jianhua Rong, Jianhao Zhao*. ATP/Hyals dually responsive core-shell hyaluronan/chitosan-based drug nanocarrier for potential application in breast cancer therapy. International Journal of Biological Macromolecules, 2021, 183, 839-851 (IF=8.025)

6. Xilin Lin, Xipeng Guan, Youheng Wu, Shuqiang Zhuang,Yuzheng Wu, Lin Du, Jiafeng Zhao, Jianhua Rong, Jianhao Zhao*, Mei Tu. An alginate/poly(N-isopropylacrylamide)-based composite hydrogel dressing with stepwise delivery of drug and growth factor for wound repair. Materials Science & Engineering C, 2020, 115, 111123 (IF 7.328)

7. Ruicong Li, Xipeng Guan, Xilin Lin, Pengyue Guan, Xiong Zhang, Zhouquan Rao, Lin Du, Jiafeng Zhao, Jianhua Rong, Jianhao Zhao*. Poly(2-hydroxyethyl methacrylate)/β-cyclodextrin-hyaluronan contact lens with tear protein adsorption resistance and drug sustained delivery for ophthalmic diseases. Acta Biomaterialia, 2020, 110, 105-118 (IF 10.633)

8. H.R. Li, X.Y. Zhang, X.L. Lin, S.Q. Zhuang, Y. Wu, Z. Liu, J.H. Rong, J. H. Zhao*. CaCO3 nanoparticles pH-sensitively induce blood coagulation as a potential strategy for starving tumor therapy. Journal of Materials Chemistry B, 2020, 8, 1223-1234. (IF 7.571)

9. Y. Wu, X. Y. Zhang, H. Q. Li, P. F. Deng, H. R. Li, T. Q. He, J. H. Rong, J. H. Zhao* and Z. Liu*. A core/shell stabilized polysaccharide-based nanoparticle with intracellular environment-sensitive drug delivery for breast cancer therapy. Journal of Materials Chemistry B, 2018, 6(41), 6646-6659 (IF 7.571)

10. Y. Wu, H. Li, Z. Rao, H. Li, Y. Wu, J. Zhao* and J. Rong*. Controlled protein adsorption and delivery of thermosensitive poly(N-isopropylacrylamide) nanogels. Journal of Materials Chemistry B, 2017, 5, 7974 – 7984 (IF 7.571)

11. T.Q. He, D. Wu, X.L. Wang, J.H. Rong, J.H Zhao*. Photo-crosslinking hyaluronan-heparin hybrid hydrogels for BMP-2 sustained delivery. Journal of Polymer Engineering2017, 37, 125-133(IF 1.624)

12. X. Yuan, R.C. Li, Z.Q. Rao, H.Q. Li, J.H. Rong, M. Tu, R. Zeng, J.H. Zhao*. Synthesis and characterization of a dually crosslinked heparin conjugated hyaluronan hydrogel for BMP-2 sustained delivery. International Journal of Polymeric Materials and Polymeric Biomaterials 2016, 65(18), 928-937 (IF 3.221)

13. Y.Z Wu, W. Xiong, H.Y. Zhou, H.F. Li, G.G. Xu, J.H. Zhao*. Biodegradation of poly(butylene succinate) film by compost microorganisms and water soluble product impact on mung beans germination. Polymer Degradation and Stability 2016, 126, 22-30 (IF 5.204)

14.  R.C. Li, X.T. Zhang, Q.Y. Zhang, H.H. Liu, J.H. Rong, M. Tu, R. Zeng, J.H. Zhao*. β-cyclodextrin-conjugated hyaluronan hydrogel as a potential drug sustained delivery carrier for wound healing. Journal of Applied Polymer Science 2016, 133, 43072-43079 (IF 3.057)

15. G.G. Xu, X. Liu, Y.Q. Lin, G.S. He, W.J. Wang, W. Xiong, H.Y. Luo, Z. Liu, J.H. Zhao*. Thermal hydrolysis of poly(L-lactic acid) film and cytotoxicity of water soluble degradation products. Journal of Applied Polymer Science 2015, 132, 42064-42071 (IF 3.057)

16.  C.H. Luo, G.G. Xu, X.H. Wang, M. Tu, R. Zeng, J.H. Rong, J.H. Zhao*. Self-reinforcement and protein sustained delivery of hyaluronan hydrogel by tailoring a dually cross-linked network. Materials Science & Engineering C-Materials for biological applications 2015, 46,316-324. (IF 7.328)

17. C.H. Luo, J.H. Zhao*, M. Tu, R. Zeng, J.H. Rong. Hyaluronan microgel as a potential carrier for protein sustained delivery by tailoring the crosslink network. Materials Science & Engineering C-Materials for biological applications 2014, 36,301-308. (IF 7.328)

18. J.H. Zhao*, W.Q. Han, M.J. Tang, M. Tu, R. Zeng, Z.H. Liang, C.R. Zhou. Structure, morphology and cell affinity of poly(L-lactide) films surface-functionalized with chitosan nanofibers via a solid–liquid phase separation technique. Materials Science & Engineering C-Materials for biological applications 2013, 33: 1546-1553 (IF 7.328)

19. W.Q. Han, J.H. Zhao*, M. Tu, R. Zeng, Z.G. Cha, C.R. Zhou.Preparation and characterization of nano-hydroxyapatite strengthening nanofibrous poly(L-lactide) scaffold for bone tissue engineering. Journal of Applied Polymer Science 2013, 128: 1332-1338 (IF 3.057)

20. J.H. Zhao*, W.Q. Han, M. Tu, S.W. Huan, R. Zeng, H. Wu, Z.G. Cha, C.R. Zhou. Preparation and properties of biomimetic porous nanofibrous poly(L-lactide) scaffold with chitosan nanofibers network by a dual thermal induced phase separation technique. Materials Science & Engineering C-Materials for biological applications 2012, 32: 1496-1502 (IF 7.328)

21. J.H. Zhao*, C.H. Luo, W.Q. Han, M. Tu, R. Zeng, Z.G. Cha, C.R. Zhou. Fabrication and properties of poly(L-lactide)/hydroxyapatite/chitosan fibers ternary composite scaffolds for bone tissue engineering. Journal of Polymer Engineering 2012, 32, 283-289 (IF 1.624)

22. J.H. Zhao*, W.Q. Han, H.D. Chen, M. Tu, S.W. Huan, G.Q. Miao, R. Zeng, Z.G. Cha, C.R. Zhou. Fabrication and in vivo osteogenesis of biomimetic poly(propylene carbonate) scaffold with nanofibrous chitosan network in macropores for bone tissue engineering. Journal of Materials Science- Materials in Medicine 2012, 23: 517-525 (IF 4.727)

23. J.H. Zhao*, C.H. Luo, Y.Q. Chen, D. Wu, C.X. Shen, M. Tu, R. Zeng. Preparation, structure and BMP-2 controlled release of heparin-conjugated hyaluronan microgels. Carbohydrate Polymers 2011, 86: 806-811 (IF 10.723)

24. J.H. Zhao, W.Q. Han, H.D. Chen, M. Tu, R. Zeng, Y.F. Shi, Z.G. Cha, C.R. Zhou. Preparation, structure and crystallinity of chitosan nano-fibers by a solid-liquid phase separation technique. Carbohydrate Polymers 2011, 83: 1541-1546 (IF 10.723)


主要著作

参编《先进生物材料》,主编周长忍,暨南大学出版社,2014


承担课题

1. 一款软膜水凝胶敷料二类医疗器械的研究开发(横向项目),115万,2022.11-2023.11(子课题)

2. 一款软膜水凝胶化妆品的研究开发(横向项目),60万,2022.09-2023.12(子课题)

3. 暨南大学人工器官及材料教育部工程研究中心开放基金(ERCAOM202212):硅氧烷水凝胶角膜接触镜的超亲水表面构建及抗泪液蛋白吸附研究,3万,2022.10-2023.09

4. 全生物降解吹膜用料配方开发(横向项目),20万,2021.05-2022.12

5. CBD环糊精原料的技术开发(横向项目),10万,2021.10-2022.12

6. 一种自增强双交联透明质酸水凝胶及其制备方法(ZL201210422101.9,专利权转让),5万,2022.03

7. 中央高校基本科研业务费(理工医)(21620104):基于亚麻籽环肽、木酚素的抗骨质疏松功效评价及骨靶向口服纳米递送体系构建,30万,2020.01.01-2022.12.31

8. 广东省自然科学基金(2019A1515011500):基于乳腺肿瘤凝血与去乳酸化的纳米药物载体研究,10万,2019.10-2022.09

9. 广州市科技计划项目(201707010264):可缓释药物和抗泪液蛋白吸附的角膜接触镜材料研究,20万,2017.05-2019.04

10. 广东省自然科学基金(2016A030313097):基于乳腺肿瘤多重环境刺激响应性释药的纳米载体研究,10万,2016.06-2019.06

11. 广东省科技计划项目(2015A010105017):温敏性纳米复合水凝胶敷料双重给药用于皮肤深度创伤修复研究,30万,2016.01-2017.12

12. 广东省科技计划项目(2015A020214014):可治疗眼病的载药型软质角膜接触镜材料研究,30万,2016.01-2017.12

13. 广东省自然科学基金(2015A030313724):新型仿生纳米纤维支架的构建及诱导骨髓基质干细胞分化与骨组织再生,10万,2015.08-2018.08合作方

14. 广东省科技计划项目(2012B040301020):塑料生物降解性能评价的环境微生物法建立及降解产物的生态毒性研究,5万,2012.01-2014.12

15. 国家自然科学基金(30900296):模拟动态应力调控骨再生因子释放对间质干细胞应答的干预机制,17万,2010.01-2012.12


发明专利

中国发明专利(第一完成人):

1. 一种自增强双交联透明质酸水凝胶及其制备方法,专利号:ZL201210422101.9(已技术转让)

2. 一种药物缓释型角膜接触镜水凝胶材料及制备方法与应用,专利号:ZL201510574111.8(已技术转让)

3. 一种可促肿瘤凝血和酶/pH双重响应性释药的纳米粒子及其制备方法与应用,申请号:201910651093.7

4. 一种促肿瘤凝血和酶/ATP双重响应性释药的纳米粒子及其制备方法与应用,申请号:201910650425.X

5. 一种电场取向壳聚糖纳米纤维及其制备方法与应用,专利号:ZL201710755048.7

6. 一种药物缓释型复合滴眼液及其制备方法与应用,专利号:ZL201611016165.3

7. 一种还原//pH多重响应性释药的核壳结构纳米粒子,专利号:ZL201610109384.X

8. 一种壳聚糖基高载药纳米粒子及其制备方法与应用,专利号:ZL201610109341.1

9. 一种温敏性双重给药纳米复合水凝胶及其制备方法与应用,专利号:ZL201510713669.X

10. 聚乳酸/壳聚糖复合纳米纤维支架及其制备方法与应用,ZL200910193944.4


国际专利:

聂红,赵剑豪,朱涛,吴琰。一种高载药量的缓释微凝胶药膏及其制备方法与应用,申请号:PCT/CN2020/090012




讲授课程

本科生课程:材料分析与表征、材料分析与表征实验、环境高分子材料

研究生课程:现代材料分析技术、波谱学、复合材料


荣誉奖励

社会职务

广东省生物医学工程学会骨科临床与材料专业委员会委员

中国生物材料学会会员

教育部学位中心博士/硕士学位论文评审专家

ACS Applied Materials & Interfaces, International Journal of Biological Macromolecules, Journal of Materials Chemistry B, Carbohydrate Polymers等国际杂志审稿人