许利耕

个人简介

近年来，在精确调控纳米材料与免疫系统的相互作用，开发基于纳米材料的肿瘤免疫治疗新策略方面开展了一系列研究，已在国际学术期刊上发表SCI论文近50篇，文章他引次数 >5000，H-index为29。其中，以第一作者和通讯作者身份在Nat. Commun., Adv. Mater., Nano Lett., ACS Nano, Adv. Funct. Mater.和Nano Today等国际权威期刊发表SCI论文19篇(1区文章14篇)，影响因子大于10的9篇，累计影响因子>200，1篇被MaterialsViews China进行了亮点报道，1篇入选“2016 Hot Articles in Nanoscale”，5篇入选ESI高被引论文。主编出版纳米生物学本科实验教材(科学出版社“十三五”规划教材)，参编中文学术专著 (科学出版社)1部，英文学术专著 (Wiley出版社)2部，授权国家发明专利4项。主持NSFC面上项目、NSFC青年科学基金、广东省自然科学杰出青年基金、广东省教育厅重点项目、中国博士后科学基金面上基金、广州市基础与应用基础研究项目和中科院纳米生物效应与安全性重点实验室开放课题各1项。应邀担任Nature Communications, Advanced Materials, ACS Nano等20多个国际著名期刊审稿人，2019年起担任广东省基金和国家自然科学基金项目函评专家。

学习经历

2008.09-2012.07 国家纳米科学中心，物理化学，理学博士

2005.09-2008.07 西北农林科技大学，细胞生物学，理学硕士

2001.09-2005.07 西北农林科技大学，动物医学，农学学士

工作经历

2019.5-至今暨南大学，化学与材料学院，教授

2017.07-2019.04 苏州大学，功能纳米与软物质研究院，副教授

2017.07-2018.07 UNC Chapel Hill(美国)，药学院，访问学者

2012.08-2017.06 苏州大学，功能纳米与软物质研究院，讲师

研究方向

1. 纳米材料的生物学效应；

2. 纳米佐剂材料的精确设计与调控；

3. 基于纳米材料的肿瘤免疫治疗新策略。

主要论文

1. Ting Liu#, Ligeng Xu#, Lizhen He, Jianfu Zhao, Zehang Zhang, Qi Chen, Tianfeng Chen*. Selenium nanoparticles regulates selenoprotein to boost cytokine-induced killer cells-based cancer immunotherapy. Nano Today, 2020, 35, 100975 (IF=16.907).

2. Yahui Yang, Yifan Wang, Ligeng Xu*, Tianfeng Chen*. Dual-functional Se/Fe complex facilitates TRAIL treatment against resistant tumor cells via modulating cellular endoplasmic reticulum stress. Chinese Chemical Letters, 2020, 31, 1801-1806 (IF=4.632).

3. Rong Yang, Jun Xu, Ligeng Xu*, Xiaoqi Sun, Qian Chen, Yuhuan Zhao, Rui Peng*, Zhuang Liu*. Cancer Cell Membrane-Coated Adjuvant Nanoparticles with Mannose Modification for Effective Anticancer Vaccination. ACS Nano, 2018, 12, 5121-5129 (IF=14.588, ESI高被引论文,他引158次).

4. Guangbao Yang#, Ligeng Xu#, Yu Chao, Jun Xu, Xiaoqi Sun, Yifan Wu, Rui Peng, Zhuang Liu*. Hollow MnO₂ as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses. Nature Communications, 2017, 8, 902. (IF=12.121, ESI高被引论文, 他引454次)

5. Jun Xu, Ligeng Xu*, Chenya Wang, Rong Yang, Qi Zhuang, Xiao Han, Ziliang Dong, Wenwen Zhu, Rui Peng*, Zhuang Liu*. Near-Infrared-Triggered Photodynamic Therapy with Multitasking Upconversion Nanoparticles in Combination with Checkpoint Blockade for Immunotherapy of Colorectal Cancer. ACS Nano, 2017, 11, 4463-4474 (IF=14.588, ESI高被引论文, 他引277次).

6. Jingjing Liu, Kai Liu, Liangzhu Feng, Zhuang Liu, Ligeng Xu*. Comparison of nanomedicine-based chemotherapy, photodynamic therapy and photothermal therapy using reduced graphene oxide for the model system. Biomaterials Science, 2017, 5, 331-340. (IF=6.183)

7. Qian Chen#, Ligeng Xu#, Chao Liang, Chao Wang, Rui Peng, Zhuang Liu*. Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy. Nature Communications, 2016, 7, 13193. (IF=12.121, ESI高被引论文, 他引593次)

8. Wenwen Zhu, Ziliang Dong, Tingting Fu, Jingjing Liu, Qian Chen, Yonggang Li, Ran Zhu*, Ligeng Xu*, Zhuang Liu*. Modulation of hypoxia in solid tumor microenvironment with MnO₂ nanoparticles to enhance photodynamic therapy. Advanced Functional Materials, 2016, 26, 5490-5498 (IF= 16.836, ESI高被引论文, 他引280次)

9. Ligeng Xu, Jian Xiang, Ye Liu, Jun Xu, Yinchan Luo, Liangzhu Feng, Zhuang Liu*, Rui Peng*. Functionalized graphene oxide serves as a novel vaccine nano-adjuvant for robust stimulation of cellular immunity. Nanoscale, 2016, 8, 3785-3795. (IF= 6.895, 2016 Hot Articles in Nanoscale)

10. Yinchan Luo, Xinxing Yang, Xiaofang Tan, Ligeng Xu*, Zhuang Liu, Jie Xiao, Rui Peng*. Functionalized graphene oxide in microbial engineering: an effective stimulator for bacterial growth. Carbon, 2016, 103, 172-180. (IF=8.821)

11. Ligeng Xu, Jian Xiang, Rui Peng*, Zhuang Liu*. Recent advances in the development of nanomaterials for DC-based immunotherapy. Science Bulletin, 2016, 61, 514-523. (Invited review, IF=9.511)

12. Jian Xiang, Ligeng Xu*, Hua Gong, Wenwen Zhu, Chao Wang, Jun Xu, Liangzhu Feng, Liang Cheng, Rui Peng*, Zhuang Liu*. Antigen-loaded upconversion nanoparticles for dendritic cell stimulation, tracking, and vaccination in dendritic cell-based immunotherapy. ACS Nano, 2015, 9, 6401-6411. (IF= 14.588, 他引120次)

13. Hua Gong, Jian Xiang, Ligeng Xu*, Xuejiao Song, Ziliang Dong, Rui Peng*, Zhuang Liu*. Stimulation of immune systems by conjugated polymers and their potential as an alternative vaccine adjuvant. Nanoscale, 2015, 7, 19282-19292. (IF= 6.895)

14. Liming Qu, Jinhai Xu, Xiaofang Tan, Zhuang Liu, Ligeng Xu*, Rui Peng*. Dual-aptamer modification generates a unique interface for highly sensitive and specific electrochemical detection of tumor cells. ACS Applied Materials & Interfaces, 2014, 6, 7309-7315. (IF=8.456)

15. Ligeng Xu, Liang Cheng, Chao Wang, Rui Peng*, Zhuang Liu*. Conjugated polymers for photothermal therapy of cancer. Polymer Chemistry, 2014, 5, 1573-1580. (Invited review, IF=4.76, 2014’s most accessed Polymer Chemistry Top10 articles,他引148次)

16. Ligeng Xu, Ye Liu, Zhiyun Chen, Wei Li, Ying Liu, Liming Wang, Liying Ma, Yiming Shao*, Yuliang Zhao*, Chunying Chen*. Morphologically Virus-Like Fullerenol Nanoparticles Act as the Dual-Functional Nanoadjuvant for HIV-1 Vaccine. Advanced Materials, 2013, 25, 5928-5936. (IF=27.398, Highlighted by MaterialsViews China, 他引64次)

17.Ligeng Xu, Ye Liu, Zhiyun Chen, Wei Li, Ying Liu, Liming Wang, Yong Liu, Xiaochun Wu*, Yinglu Ji, Yuliang Zhao, Liying Ma, Yiming Shao, Chunying Chen*. Surface-engineered gold nanorods: promising DNA vaccine adjuvant for HIV-1 treatment. Nano Letters, 2012, 12, 2003-2012. (IF=11.238, 他引181次)

18. Ligeng Xu, Chunying Chen*. Physiological behavior of quantum dots. WIRES Nanomedicine Nanobiotechnology, 2012, 4, 620-637. (Invited review, IF=7.689, 他引5次)

19. 许利耕, 陈春英*. 纳米材料作为重大疾病疫苗载体或佐剂的研究进展. 科学通报, 2012, 57, 2341-2353 (封面文章).

20. 刘庄, 许利耕, 主编。《纳米生物学交叉实验教程》, 科学出版社(普通高等教育 “十三五”规划教材), 2017, ISBN: 978-7-03-055171-9.

21. Ligeng Xu, Xuejiao Song, Zhuang Liu*. Chapter 11: Conjugated Polymers for Near‐Infrared Photothermal Therapy of Cancer. In: Conjugated polymers for biological and biomedical applications. Wiley-VCH Verlag GmbH & Co. KGaA, 2018, ISBN: 978-3-527- 34273-0.

22. Ligeng Xu, Chunying Chen*. Chapter 8: Modulation of the immune system by fullerene and graphene derivatives. In: Biomedical applications and toxicology of carbon nanomaterials. Wiley-VCH Verlag GmbH & Co. KGaA, 2016, 213-238, ISBN: 9783527338719.

23. 许利耕, 陈春英*.《二氧化钛纳米材料的制备、表征及安全应用》(第六章: 二氧化钛纳米材料与生物体的相互作用及其与纳米特性的相关性), 科学出版社, 2014, ISBN: 9787030400710.

承担课题

1. NSFC面上项目：基于二氧化锰多功能纳米材料的肿瘤新抗原疫苗及其免疫联合治疗新策略，2019.1.1~2022.12.31

2. NSFC青年科学基金：功能化氧化石墨烯作为新型纳米佐剂在肿瘤DNA疫苗中的研究, 2014.1.1~2016.12.31

3. 广东省自然科学基金杰出青年基金：多功能纳米硒的精确设计与调控及其肿瘤疫苗治疗新策略，2021.01-2024.12

4. 广州市基础与应用基础研究项目：基于硒纳米材料的新型肿瘤疫苗佐剂研究, 2020.04-2023.04

专利

1. 刘庄, 许利耕, 陈倩, 彭睿. 一种二氧化锰纳米佐剂及其制备方法、应用. 专利申请号：CN201710795715.

2. 陈春英, 许利耕, 吴晓春. 金纳米棒的修饰方法及金纳米棒-功能分子复合体. 专利授权号：ZL201010274005.

3. 陈春英, 许利耕. 纳米颗粒的制备方法及用该方法制备的纳米颗粒. 专利授权号：ZL201010274003.

4. 陈春英, 邵一鸣, 许利耕, 郝彦玲, 刘颖, 刘野. 富勒烯衍生物在制备用于基因传递的载体中的应用. 专利授权号: ZL201010621120.5.

5. 陈春英，邵一鸣，许利耕，郝彦玲，刘颖，刘野. 富勒烯衍生物及其疫苗佐剂和疫苗制剂.专利授权号: ZL201310357325.

讲授课程

《化学生物学》(本科生、研究生课程)

荣誉与奖励

1. 广东省自然科学杰出青年基金获得者 (2021年)；

2. ACS Nano Young Scientist Award (International Conference of ChinaNanomedicine 2016, 武汉)；

3. 苏州市自然科学优秀学术论文二等奖 (2016年)；

4. 苏州大学教学优秀奖 (2015年)。